PRGF (Platelet Rich in Growth Factors) treatment is an innovative biological therapy involving the application of specially enriched plasma, derived from the patient’s own blood, directly to damaged tissue. This plasma is particularly rich in growth factors, promoting accelerated tissue repair, regeneration, and pain reduction. PRGF significantly differs from traditional PRP (Platelet Rich Plasma) treatments due to being leukocyte-free (free of white blood cells) and offering sustained release of growth factors.
So, what exactly is PRGF, how does it differ from PRP, what conditions does it treat, and how does the treatment process work?
In this article, you will find comprehensive answers to all your questions about PRGF treatment, exploring its benefits, applications, and key considerations.
What is PRGF?
PRGF injection is a specialized type of PRP therapy, specifically “Platelet Rich in Growth Factors.” The most significant distinction between PRGF and traditional PRP is the absence of leukocytes (white blood cells) and a higher concentration of growth factors.
PRGF treatment involves a balanced and sustained release of growth factors and other proteins. Platelets injected via PRGF continue to release growth factors for approximately 10 days. PRGF is classified as leukocyte-poor PRP and can be formulated into three different forms: liquid, gel, and fibrin. Platelet concentration in PRGF is typically 3-5 times higher than normal blood levels.
Like PRP, PRGF is prepared from the patient’s blood using specialized centrifuge equipment and a distinct centrifugation protocol. Prior to injection, a small amount of calcium chloride is added to activate platelet cells.
Differences Between PRGF and PRP
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Leukocyte-Free:The most critical difference is the absence of leukocytes in PRGF. Leukocytes often cause inflammation at the application site. Since reducing inflammation is a crucial therapeutic goal, leukocyte-free PRP derivatives such as PRGF are preferred.
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Extended Release of Growth Factors:In PRGF, growth factor concentration peaks around the third day after application and continues increasing until approximately the sixth day.
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Antibacterial Effect:PRGF possesses antibacterial properties, offering protective effects against potential microbial contamination and infection during treatment.
Conditions Treated by PRGF
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Knee Joint: Osteoarthritis, ligament injuries (particularly medial and lateral collateral ligament tears), ACL injuries not requiring surgery, non-mechanical meniscus tears, cartilage injuries, patellar tendinitis, quadriceps tendinitis.
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Shoulder Joint: Rotator cuff tears, supraspinatus tendinosis, biceps tendinosis, SLAP tears, osteoarthritis, labrum tears associated with shoulder dislocation.
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Elbow Joint: Tennis and golfer’s elbow, cartilage issues.
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Hip Joint: Osteoarthritis, labrum tears.
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Ankle Joint: Ligament tears, cartilage issues.
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Muscle Tears: Common sports-related muscle tears in hamstring, quadriceps, and calf muscles.
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Delayed Union Fractures: To accelerate bone healing in slow-healing fractures.
Surgeries Utilizing PRGF
PRGF enhances surgical outcomes, increasing success rates and accelerating recovery. During surgery, PRGF is commonly applied in its fibrin form.
Typical surgeries utilizing PRGF include:
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Shoulder supraspinatus tendon repair
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SLAP tear surgeries
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Elbow ligament repair
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Hip labrum repair
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Hamstring and quadriceps tendon repair
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Knee ligament repair
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Meniscus repair
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Ankle ligament repair
How is PRGF Injection Performed?
After preparing PRGF, the material is transferred into a syringe. The PRGF is usually administered under ultrasound guidance to ensure precise application to the targeted area.
Using ultrasound significantly enhances the success rate of the PRGF injection by ensuring accurate placement.
You can view an example of PRGF injection for knee osteoarthritis performed by Op. Dr. Utku Erdem Özer below.
Cost of PRGF Treatment
The cost of PRGF treatment may vary depending on specific medical conditions, the clinic, and the extent of the procedure. Please consult your healthcare provider for detailed pricing.
Conclusion
PRGF treatment represents a significant advancement in regenerative medicine, providing numerous advantages for various musculoskeletal conditions through its unique properties. Discuss with your healthcare provider to determine if PRGF therapy is suitable for your condition.
